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All GLP-1 class drugs cause some degree of lean mass loss alongside fat loss, and this is a legitimate concern for anyone optimizing for longevity rather than just the number on the scale
Below are some common questions regarding these treatments
The SURPASS clinical trial program, which evaluated tirzepatide in over 10,000 patients with type 2 diabetes, did not identify palpitations as a significant safety signal
Slipped capital femoral epiphysis (SCFE, rare but serious): This orthopedic complication is a known risk with any GH-axis stimulation therapy in adolescents, particularly in overweight male patients
The fact that weight loss improves metabolic health, which might help restore ovulation in infertile women, may also play a role
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