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Richard Frank, MD, MHSA, Chief Medical Officer at Vida Health, spoke to Medical News Today about how orforglipron may expand access to GLP-1s: The choice between a pill and an injectable comes down to patient preference and potency. The injectables are clearly more potent but require a weekly injection

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The counter-argument is that a second receptor pathway is a second source of variability in effect, in tolerability, and in long-term safety questions

Proactive supplementation is not optional, it is necessary

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