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Fibroblast Growth Factor 21 Reduces Hepatic Steatosis and Lipotoxicity Administration of FGF21, FGF21 analogs or adenoviral delivery of FGF21 reduces hepatic steatosis in diverse rodent models of NAFLD and NASH (101, 126129)

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Binding of leptin produces a feeling of satiety after a meal, thereby reducing appetite

Mechanism of Action: Modulation of HGF Signaling Pathways This brake removal mechanism has important implications for research design