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From SURMOUNT-1 reanalysis at week 4: 2.5 mg arm: average weight change -1.2% (about 2.5 lb for a 200 lb starting weight) 5 mg arm: average weight change -2.1% (about 4.2 lb) 10 mg arm: average weight change -2.6% (about 5.2 lb) 15 mg arm: average weight change -2.9% (about 5.8 lb) Placebo arm: average weight change -0.4% The headline 21% weight loss number from SURMOUNT-1 is the 72-week result at 15 mg

found that ipamorelin can stimulate GH release in animals (swine and rats) to an extent comparable with GHRP-6 [3]

Both cost $1,069/month and produce identical results

Ann Intern Med 1999

For example, taking half the daily fiber supplement in the morning and half in the evening distributes the gastrointestinal effects and may improve tolerance