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Lesovaya EA, Savinkova AV, Morozova OV, Lylova ES, Zhidkova EM, Kulikov EP

It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]

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These results thus validated that the core mechanism by which pro-inflammatory neutrophils exacerbate pancreatic dysfunction in diabetes is intracellular GSH accumulation within the neutrophils