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While cross-trial comparisons always carry methodological caveats (different patient populations, study designs, and timeframes), the magnitude of the difference is large enough to draw clear conclusions

However, in response to stress p66Shc translocates to mitochondria to contribute to the generation of H 2 O 2

The peptide affects gut motility and secretion, which may add to its effects on gut health

Most gastrointestinal symptoms improve over several weeks as the body adjusts, though some patients find them intolerable and discontinue treatment