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Higher retatrutide doses (10-12 mg) produce more GI side effects and carry a higher risk of dysesthesia (tingling/numbness) without engaging the amylin pathway
This is particularly important if you have: Underlying gastrointestinal conditions : Such as inflammatory bowel disease (Crohn's disease or ulcerative colitis), short bowel syndrome, or a history of intestinal surgery
Semaglutides and tirzepatides are medications originally developed to treat type 2 diabetes but are now widely used for weight loss due to their effects on appetite control and metabolism
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