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2023 titled Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol, improvements in cognition and thiamine blood levels have been observed over about 14 days of supplementation

The copper ion is not incidental, it is part of how the molecule delivers both the signal and the material for repair

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European Journal of Endocrinology/European Federation of Endocrine Societies, 168 (5), 10.1530/EJE-12-1037

GHK-Cu's collagen remodeling is producing visible changes