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The use of weight loss injections for chronic kidney disease patients uk in these advanced stages is generally restricted
Holding at a dose for an extra 4 weeks before escalating is a medically supported strategy when: Nausea or vomiting persists beyond 2 weeks at the current dose You are unable to eat at least 1,000 calories per day comfortably Dehydration symptoms appear (dark urine, dizziness on standing, dry mouth) You are losing weight faster than 1 to 2 pounds per week on the current dose (aggressive weight loss increases side effect risk) In the STEP trials, delayed escalation did not compromise overall weight loss outcomes at 68 weeks
This prevents the severe nausea that can occur when GLP-1 receptors that have desensitized during the break are suddenly hit with a high dose again
What are bellwether trials
PMID: 38639975.
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