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76 For instance, AARS1 functions as an intracellular lactate sensor, directly binding lactate to form lactate-AMP, and mediates lactylation of K120/139 on p53 within its DNA-binding domain (DBD), which prevents the binding of p53 to DNA containing p53 response elements (p53RE-DNA) and subsequent p53 liquidliquid phase separation (LLPS)
ACS Catalysis 13 , 36273643 (2023)
Iron supplementation should be guided by laboratory testing (ferritin, complete blood count) rather than empiric use
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