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The linker region of GSDMD is cleaved by inflammatory caspases, releasing its active N-terminal domain
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Nat Rev Dis Prim
However, the study affirms that EGCG is generally well tolerated in humans and supports the idea that EGCG therapy acting on the -synuclein oligomer formation may be an effective target for the treatment of neurodegenerative diseases (225)
H1 blockers include cetirizine (Zyrtec), loratadine (Claritin), levocetirizine (Xyzal), fexofenadine (Allegra) or chlorphenamine (Chrorphen)
