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For biosynthesis, it seems the only strategy to prolong the half-life is a ligand fused with a terminal albumin or Fc domain, whose critical points are length and location
Across the literature the components appear under several alternate names
However, extreme exhaustion persisting beyond week 8, combined with muscle weakness, severe headaches, or shortness of breath, warrants immediate medical attention
Well-powered, controlled trials are needed to confirm efficacy and safety, identify optimal subgroups, and evaluate long-term outcomes
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