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Autophagy is initiated by the autophagy-activating protein complex that includes the UNC-51-like kinase (ULK1), autophagy-related protein 13L (ATG13L), family interacting protein of 200 kDa (FIP200), and ATG101 [254]
selected an optimized n-hexane-ethyl acetate-methanol-water (3:7:4:6, v/v) solvent system for countercurrent chromatography based on partition coefficients (k) and separation factors (), utilizing the lower phase as mobile phase in head-to-tail elution mode, where 400 mg crude extract yielded pure senkyunolide-I (6.4 mg, 98%) and senkyunolide-H (1.7 mg, 93%) in a single run (32)
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Aberrant activation of BCAT 1 was similarly detected in CML
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