The patients who report the strongest response are those who are already active, eat well, and are looking to optimize cellular energy output rather than compensate for lifestyle gaps
A meta-analysis across randomized controlled trials found significant reductions in body weight averaging 12.4%, BMI by 4.0 kg/m2, and waist circumference by 8.0 cm
Many charts do not explain screening criteria, adverse-event rules, missed-dose handling, or why investigators chose a particular pattern
However, some people may continue to experience ongoing GI side effects, lasting several weeks to months
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