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This paper highlights the novel implications of metabolic modulations and their potential to alter the CAR T cell characteristics during manufacturing, resulting in a less exhausted, memory-like phenotype with enhanced effector functions, which could significantly improve CAR T therapy (Summarized in Table 2 )

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Glutathione is so crucial in fact, that even moderately lower-than-normal levels can result in the systematic breakage of cells, while extremely poor levels result in cell death

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CrossRef Monitoring the Outcomes of Systemic Chemotherapy Including Immune Checkpoint Inhibitor for HER2-Positive Metastatic Gastric Cancer by Liquid Biopsy Seung-Hyun Jung, Choong-kun Lee, Woo Sun Kwon, Sujin Yun, Minkyu Jung, Hyo Song Kim, Hyun Cheol Chung, Yeun-Jun Chung, Sun Young Rha Yonsei Medical Journal.2023