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Some users report improved energy within the first week, while others may not notice significant changes for a month or more
For patients who were overweight or obese, the incidence was 6.7% with semaglutide compared to 0.8% with non-GLP-1 weight-loss medications
p = 0.04), indicating a notable advantage of Tirzepatide over Semaglutide in reducing HbA1c levels, with a large difference in efficacy between the two medications (Figure 10)
GLP-1 for weight loss Medically reviewed by Dr Crystal Wyllie Last reviewed: 19 Jun 2026 Glucagon-like peptide-1 (GLP-1) agonists are a popular weight loss treatment in the UK
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