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After careful review, 5 studies were found eligible for the review ( Figure 1 )
Zepbound (tirzepatide) is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist-the first and only approved treatment activating both incretin hormone receptors
Retatrutide is a triple-receptor agonist, meaning it simultaneously activates three distinct hormone receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and the glucagon receptor
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