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330,331 Increased glucose uptake by TAMs triggers the hexosamine biosynthetic pathway (HBP), enhancing O-GlcNAcylation of Cathepsin B, which promotes lysosomal secretion and fosters metastasis and chemoresistance

The Canadian recommendations align with international guidelines, best practices, and standards.85 87 Gaps in knowledge Evidence regarding the potential benefit of obesity pharmacotherapy is lacking in several important subpopulations, including polycystic ovary syndrome, chronic kidney disease, gastroesophageal reflux disease, and depression

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