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This evolution is driven by selective pressure from antibiotic use, with factors such as decades of overuse, incorrect dosing, and the widespread use of antimicrobials in livestock, contributing to the selection of resistant strains
Pro-inflammatory cytokines are associated with several diseases such as renal disease, 3 obesity, 4 and inflammatory bowel disease
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However, many peptides work locally, never reach the blood stream, and would never be called hormones
Aging Cell (2014) 13(4):66978
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