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Inflammatory factors, prostaglandins, bradykinin, and proteases upregulate these receptors in UC and CD patients ( PPAR- agonists have been shown to reduce fibrosis in many organs, including the intestines, while selective PPAR- antagonists abolish these effects ( A similar result was obtained by examining the effect of PPAR- activation with ajulemic acid, the non-psychoactive synthetic analogue of THC in skin fibrosis ( Table 2 summarizes the preclinical studies discussed in the manuscript
Side effects are uncommon and typically mild, such as slight redness or discomfort at the injection site
Jukes-Jones, S.M
