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Further data on the efficacy and safety of semaglutide in T2D subjects with renal dysfunction were provided by PIONEER 5 trial [18]
Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]
Excess fat may activate the sympathetic nervous system (SNS), increasing heart rate and causing other cardiovascular changes which contribute to high blood pressure
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Secondly, this study was limited to changes in E
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