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A lack of antioxidants, and with it glutathione, exacerbates this damage, causing scarring of the tissue and an even more serious condition called cirrhosis
However, such benefits are counterbalanced by risks: P-gp-mediated drug efflux, a key contributor to therapeutic resistance for drugs like MAO inhibitors and anticancer agents, can be modulated by nutraceuticals like PPR and QUE (81, 88)
Patients who are already managing the once-weekly injection cadence of Semaglutide or Tirzepatide and do not want to add daily injections are not good candidates for GHK-Cu, not because of any contraindication, but because they wont maintain the protocol consistently enough to see results
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