[66] The beverage has initial numbing and astringent effect in the mouth caused by the local anesthetic action of kavalactones and chewing it has local anesthetic effects similar to that of cocaine and longer lasting than benzocaine
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All mice were housed at the Translational Research Institute, Biological Research Facility (Queensland, Australia) under specific pathogen-free conditions with ad libitum access to water and a standard diet chow (Specialty Feeds, Western Australia, Australia) and simulated 12-h light and dark cycles
Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity