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Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research
In the first stage, the formation of free radicals is hindered by the maintenance of appropriate redox potential in the cells, in which antioxidant enzymes play an important role
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We summarize how intracellular lipolysis affects lipid-mediated signalling, metabolic regulation and energy homeostasis in multiple organs
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However, its most fascinating and clinically relevant functions occur within the central nervous system, where it acts as a highly specialized dual-role neurotransmitter
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