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A: The copper component is essential for GHK-Cus biological activity
7 , structure 1 ), which is currently undergoing multiphase 2 clinical trials for the treatment of Meniere's disease (Kil et al
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That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119
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