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Unfortunately, HIF-1 effectively promotes various immune suppressive pathways including secretion of immune suppressive cytokines, activation of myeloid-derived suppressor cells, activation of regulatory T cells, inhibition of T cells priming and activity, and upregulation of immune checkpoints

For each standard deviation decrease in telomere length, the risk of diabetes increases by 37%.[ref] Bipolar disorder shows associations with significantly shorter telomere lengths.[ref] PTSD from sexual assault or childhood trauma (but not combat) is associated with shorter telomere length.[ref] Various different cancers have associations with shortened telomeres, possibly because shortened telomeres could cause more DNA instability.[ref] To sum this up, studies show that shortened telomeres are associated with: heart attack stroke atherosclerosis type 2 diabetes depression bipolar disorder cancer The chicken and egg question comes to mind here: Are the above diseases causing the telomeres to shorten or are the shorter telomeres causing the disease

10.1159/000192953 46 PugazhenthiS.NesterovaA.SableC.HeidenreichK