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Alvarado AG, et al
Lowers a signaling protein (TGF-1) and reduces cell stress (measured by an antioxidant enzyme called SOD), both of which contribute to hair follicles shrinking due to the hormone DHT
Schmitt et al
Predictive computational tools are emerging to de-risk these platforms, but thorough in vivo assessment is indispensable ( 4 Challenges, future directions, and the promise of precision medicine 4.1 Key challenges in targeting oxidative stress for MIRI treatment Despite compelling preclinical evidence highlighting the central role of oxidative stress in MIRI pathophysiology, translating these findings into effective clinical therapies has proven remarkably challenging, largely contributing to the unmet promise observed thus far
Importantly, autoradiographic analyses in the basal ganglia and cortex of RS patients showed reduced density of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA), and GABA receptors [375]
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