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Core body temperature drops
Novo Nordisk may have first-mover advantage in the oral space, with oral Wegovy (obesity) and Rybelsus (T2D, launched 2019), but orforglipron is expected to outperform these on-market semaglutide options for a number of reasons: superior HbA1c reduction and weight loss
No participants developed antibodies against the peptide, and no serious adverse events led to treatment withdrawal
The study was funded through a Novo Nordisk research grant to the Groninger Medical University Center
Rapid weight loss can also signal stress to the body, prompting it to conserve energy, including by dialing back reproductive functions
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