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Those three human pilots include: a Phase I safety study in healthy volunteers (2003, well-tolerated)

Combination with conventional care: Maintain proper immobilization, weight-bearing restrictions, nutrition optimization (calcium, vitamin D, protein), and physical therapy as prescribed

Endocrine journal, 60(3), 311319

While Zepbound (the obesity-specific brand) received FDA approval in the United States, Canadian obesity indication approval follows different timelines