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1) 2) CANCER : methotrexate is a structural analog of folic acid and at the high concentrations used in cancer chemotherapy it competitively inhibits the binding of dihydrofolic acid to dihydrofolate reductase (Furst et al., 2012)
Clinical trials show clear increases in GI side effect incidence as doses escalate from 5 mg to 15 mg
Focus on the laughter, not the liquid
J Mol Liquids (2021) 322:114501
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