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While the etiology of OPLL is generally considered multifactorial, there is no consensus regarding these contributing factors including genetic, endocrine, biomechanical, immune and lifestyle factors

Acknowledgements This work was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre

Experimental evidence suggests an involvement in vascular remodeling through stimulation of new microvessel development, alongside regulation of nitric oxidedependent signaling

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