Horowitz AJ, Smith T, Frey D
NOCA4 attaches to ferritin and is destroyed by ferritin phagocytosis (76), eventually releasing free iron to participate in the Fenton reaction, which generates ROS and increases the accumulation of intracellular lipid peroxides (LPOs) and ferroptosis (77) ( Figure 2 )
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It helps replenish other antioxidants, such as vitamin C, E, etc., boosting the cell's defense power