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An -hydroxy acid sometimes produced at high levels by cancer cells, which structurally resembles -ketoglutarate and so inhibits -ketoglutarate-dependent enzymes such as the Jumonji-family histone demethylases
But acne can happen to anyone, even affecting people in their 30s and 40s
The peptides proposed mechanism involves activation of the VEGFR2 pathway (promoting angiogenesis), nitric oxide synthesis via the Akt-eNOS axis, and modulation of the dopaminergic system
But again, meta regressions aren't perfect because you're kind of like extrapolating all these numbers that are in different kind of heterogeneous studies and you're trying to come up with a dose response
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