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Psychiatry 29 , 10051019 (2024)
However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
Therapeutic interest: Initially studied for Alzheimers disease and other neurodegenerative conditions, Dihexa has since gained attention in the nootropic and performance communities for its potential role in learning, memory, and brain repair
Neither compound has a supported oral or sublingual form
Rather than the usual alpha-carboxyl linkage found in ribosomal peptides, the amide forms between the side-chain gamma-carboxyl of glutamate and the amino group of cysteine
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