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The inhibitory activity was recognized to the amino acid moiety, alanine-containing compounds being two to three folds weaker than glycine-containing compounds [92]
The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
Intended for maintenance treatment at the 1 mg dose only
Cardiovascular adaptation represents another consideration for extended use
When GLP-1 interacts with GLP-1R, this triggers cyclic adenosine monophosphate (cAMP) formation and initiates subsequent pathways (2)
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