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De bindingsaffiniteit verschilt per receptorsubtype: MC1R (Ki = 0,67 nM), MC4R (Ki = 6,6 nM), MC3R (Ki = 34 nM) en MC5R (Ki = 46 nM)

In the SURMOUNT-1 trial, tirzepatide at 15 mg achieved a mean weight reduction of 20.9%, approximately 6 percentage points above semaglutide's best result in comparable populations

Levothyroxine replaces missing thyroid hormone to restore normal metabolism, whilst GLP-1 receptor agonists like semaglutide (Wegovy) and liraglutide (Saxenda) work by reducing appetite and promoting weight loss

Optimal results occur with consistent use over 3-6 months, as GHs effects are cumulative and require time for tissue remodeling