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Endocrine Endocrine dysfunction is frequently reported in patients receiving ICIs (5%-20%), with an average onset time within 12 weeks from treatment initiation, and higher incidence in patients receiving combination therapy compared with monotherapy
Research indicates that apigenin effectively inhibits CD38 in mice, leading to significant increases in NAD + levels 143,144
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-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early-or late-life stress
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