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Problems with systemic anti-melasma agents Although most of these systemic agents are devoid of serious adverse effects, probably with the exception of glutathione, their use as a skin-whitening agent for the treatment of melasma is not yet approved by the United States Food and drug administration (USFDA).[] However, their unregulated use by untrained people may lead to several lethal complications such as sepsis, air embolism, transmission of human immunodeficiency virus and Hepatitis B (parenteral formulations)
This means that there is potential for the use of this supplement to prevent cardio-cerebrovascular diseases while being cautious not to give these supplements to patients who suffer from low platelet count or bleeding disorders (Juan and Shanzhang, 1995)
Natural organic or inorganic compounds with loose porous structures are ideal for drug-loaded MNMs
Carnitine metabolism in uremia
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