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Research Support and Efficacy Numerous clinical trials have demonstrated the effectiveness of semaglutide for weight loss: Clinical Trials : In a pivotal study involving approximately 2,000 adults with obesity or overweight (without diabetes), those using semaglutide in conjunction with lifestyle modifications lost an average of 14.9% of their body weight over 68 weeks, compared to a mere 2.4% weight loss in the placebo group

Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM

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By activating the GLP-1 receptors, semaglutide sends signals to the brain that induce a sensation of satiety, leading to reduced calorie intake and, consequently, weight loss