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Among resmetirom-treated patients with a 120% increase in SHBG (marker of drug exposure), NR was seen in 34% and 37% and FR in 22% and 20% more resmetirom 80mg and 100mg patients than placebo

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Safety Signals in Phase II While efficacy was impressive, the trials also raised important safety concerns: Heart rate increases: Mean increases of 7.4 bpm (0.5 mg) and 9.1 bpm (1.0 mg) versus placebo Blood pressure: Modest systolic increases at higher doses Psychiatric effects: Insomnia (2135%), dry mouth (3044%), and mood changes in some patients Gastrointestinal: Nausea, diarrhea, and constipation at rates above placebo The cardiovascular signal particularly the heart rate increase would become the central obstacle in tesofensine's regulatory path

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The presence of health disparity is apparent in PCa incidence