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SIRT6-null hMSCs showed a premature cellular attrition and could be rescued by overexpressing HO-1, suggesting that an imbalance of ROS levels could result in stem cell decay [125]
These findings underscore lipid peroxide accumulation as a hallmark of ferroptosis, and suggest that downregulating ACSL4, LPCAT3, LOXs, or POR can suppress PUFA-PL-OOH formation and effectively inhibit ferroptosis
Severity of BED was determined based on having at least 3 binge days per week for 2 weeks prior to the baseline visit and on having a Clinical Global Impression Severity (CGI-S) score of 4 at the baseline visit
Glutathione has been studied extensively due to its role as an antioxidant
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