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The MASTERS trial [106] also found no augmentation of muscle strength when metformin 850 mg twice daily was added to a 14-week resistance training programme for older men and women, and indeed the muscle hypertrophic response measured by both computed tomography and by DXA to exercise was blunted by metformin when compared with placebo

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In addition, we synthesize current findings on organelle-specific zinc dysregulation and its associated pathological consequences