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the membrane-bound form of the molecule for the various functions of DPP-4 has not been clarified, nor is it clear whether (or to what extent) changes in circulating levels of soluble DPP-4 might be regulated (e.g., whether they simply reflect alterations in non-specific cleavage or shedding of the membrane-bound form or whether this is a process which might be modulated in response to pathological processes or changes in metabolic status)
Study: Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review
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