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Molecular size directly limits mucosal permeability, and peptides above a certain threshold do not cross the sublingual epithelium in clinically predictable amounts
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The addition of homocysteine causes some proteins to become pro-inflammatory or pro-thrombotic.[ref] Oxidative stress, ER stress, and mitochondrial dysfunction: High homocysteine levels are also associated with increased oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress
Hernantz A, Fernandez-Vivancos E, Montiel C, Vazquez JJ, Arnalich S: Changes in the intracellular homocysteine and glutathione content associated with aging
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