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Dropping from 2.4 mg to 1.7 mg or 1.0 mg often reduces constipation to manageable levels while maintaining most of the weight loss effect

Microdosing GLP-1 helps calm appetite spikes, stabilize insulin response, and make body recomposition feel a bit more achievable without the heavy side effects that come with full medical doses

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A 2018 review in the International Journal of Molecular Sciences compiled transcriptome-profiling data showing thousands of human genes flagged as up- or down-regulated under GHK-Cu exposure across multiple cell-type studies, framing the compound's pleiotropy at the regulatory-network level (PMID 29986520)