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JAMA 331 , 654664 (2024)
Overall prescribing trends The study found that 1,828,203 patients were prescribed a GLP-1 RA between January 2018 and December 2024, with 8,412,584 total prescriptions during this period
Patients who survive often recover completely, although recovery can be prolonged
instead, the excess unabsorbed carnitine will simply pass into the large intestine or be excreted by the kidneys
Intestinal microorganisms metabolize TML into trimethyl-5-aminovaleric acid (TMAVA), which can competitively inhibit the binding of -BB to BBD, thereby inhibiting carnitine biosynthesis and FAO in the liver, promoting steatosis and aggravating fatty liver [250]
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