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IDegLira currently carries a black-box warning for risk of thyroid c-cell tumors related to liraglutide, and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma and in patients with multiple endocrine neoplasia syndrome type 2

REVERSE T3 (RT3) TSH and serum T4 levels do not correlate well with intracellular thyroid levels

The use of different model systems increases the confidence in translation from mouse to human studies

These outcomes could transition to us successfully, but most human evidence is anecdotal