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For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation
Its main active ingredient is Dihexa peptide, which usually exists in the form of white powder with high purity (HPLC purity 95.0%)
1 ), hemoglobin and other proteins are damaged, and eventually the red cell becomes prey to macrophages or hemolyzes altogether
10.1016/j.mito.2021.09.009 250 XieY.KangR.KlionskyD
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