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Semaglutide activates GLP-1 receptors in the hypothalamus (appetite), brainstem (fullness/nausea), pancreas (insulin), stomach (gastric emptying), and targets in the heart, liver, and kidneys
USA 113 (22), e3130e3139
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The good news is that severe side effects are very rare, including joint and muscle aches and pains, numbness, and swelling
It may also be used to treat other conditions, such as pernicious anemia, vitamin B12 malabsorption, and certain types of nerve pain
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