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Clinical Update 9/02/2022 CoQ10 for Statin-Related Muscle Pain
An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]
Furthermore, our work confirmed previous observations that the reductive metabolism of TNBS by specific flavoproteins, eg, GSSG reductase, generates ROS, including hydrogen peroxide (Grisham et al, 1991)
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